Introduction

Cerebrospinal fluid is a clear and colourless liquid, low in protein composition that is actively secreted in specific areas of the central nervous system (CNS) and surrounds the brain and spinal cord. There are 3 meninges (layers) covering the CNS whose primary function is to protect it. These 3 meninges are:

  • Dura mater
  • Arachnoid mater
  • Pia mater

Cerebrospinal fluid flows between the arachnoid mater and pia mater meninges in an area called the subarachnoid space.

Tissue layers of the head - meningeal layers are the bottom 3

Image courtesy of Wikimedia Commons under the Creative Commons Attribution License

Cerebrospinal fluid constitutes all the intracerebral, interventricular and intracisternal content. It is also present within sulci and the central canal of the spinal cord. Within the brain are fluid-filled caverns and canals that constitute the ventricular system through which cerebrospinal fluid also flows.

Ventricular system of the brain

Animation courtesy of Wikimedia Commons under the Creative Commons Attribution License

Intraentricular system of the brain

Red areas of the animation indicate the 2 lateral ventricles.

Blue areas of the animation indicate the interventricular foramina, third ventricle, cerebral aqueduct and fourth ventricle


News

03/10/2011 17:02

Cerebrospinal fluid guides stem cell development in the brain

  Cerebrospinal fluid—the clear and watery substance that bathes the brain and spinal cord—is much more important to brain development than previously realized. Howard Hughes Medical Institute investigator Christopher Walsh, his postdoctoral fellow Maria Lehtinen, former student Mauro...

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12/05/2011 17:09

HIV detectable in the cerebrospinal fluid of 10% of all AIDS patients

Ten per cent of patients taking antiretroviral therapy who have an undetectable viral load in their blood have detectable levels of HIV in their cerebrospinal fluids, Swedish and US investigators report in the online edition of the Journal of Infectious Diseases. Detectable viral load – or viral...

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04/03/2011 17:12

Cerebrospinal fluid neurofilament levels predicts neurological deterioration

In a study designed to explore the potential of several molecules as biomarkers for HIV-mediated cognitive impairment, researchers at John Hopkins University, in Baltimore, Maryland, have documented "surprisingly high levels" of neuronal heavy chain neurofilament (neurofilament H) in the...

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